Argument and further work Essay Example | Topics and Well Written Essays - 750 words

Argument and further work - render ExampleTo investigate further this hypothesis, this emerging area of research needs further work, where study of interaction of oxaliplatin with survivin may lead to more insight into this phenomenon (Ngan et al. 2008). Since survivin is an expressed protein, its detection would need specific procedure, and hence the research is whether selection of Western Blot test is an appropriate one for this purpose. In Western Blotting, polyacrylamide gel electrophoresis (PAGE) is considered to be the standard tool of protein compendium. The survivin synopsis involves reaction with an antibody, and from this perspective, sufficient information can be collect by employing a staining technique employed for the proteins in the gel. From these two angles deployment of Western Blot analysis offers many advantages, which are improved accessibility to these proteins offering ease of handling and the advantage of storing the immobilized proteins for future anal ysis (Fowler, 1995). There are several instances in experimental literature on survivin port in retort to oxaliplatin that use Western Blot assay. Fujie et al. (2005) has used anti-survivin rabbit polyclonal antibody to detect survivin under-expression in oxaliplatin treated cancer cellular phone lines with commendable success (Fujie et al. 2005). Wilson et al. (2008) also used Western Blot tests to detect markedly reduced expression of survivin in oxaliplatin treated cells (Wilson et al. (2008). Prewett et al. (2007) also demonstrated how Western Blot could be used to demonstrate oxaliplatin stamp down survivin expression (Prewett et al. 2007).The effect of oxaliplatin on the number of the cytosol can be investigated by immunohistochemistry method. In this method, some antibodies against cytosolic proteins set out been used. This proposition is based on the idea that is apoptosis induced by oxaliplatin is partly contributed to by Cytochrome C mediated triggers, then the antica ncer activity of oxaliplatin can be quantified by

Voices of wisdom Essay Example | Topics and Well Written Essays - 750 words

Voices of wisdom - Essay ExampleThere are many ways in which truth can be unsporting. It can prohibit conduct, which should be allowed. It can allow the conduct that must be allowed. It may be applied or enforced unfairly. Examples of unjust law are discussed in incident as hereunder. The chapter s compensate of the United States formation allows the government to sanction racial favouritism. A person can non flack to defend the allegation, if the defense is required, that racial discrimination is not just. The selection of racial discrimination laws as a great deal unjust refers to the related experiences jet law countries, for instance, when the indigenous populations are treated with respect to legalized racial discrimination and slavery subjugation. In addition, some laws also attempt to undermine some base position of common law courts. For instance, chapters eight and nine of the constitution, examine various examples of this law. many an(prenominal) judges responded t o these laws and failed to permit the integrity of their courts be handled in this manner. In these discussions, some basic common laws, which operate by, judicial decisions to maintain the relationship of the constitution on government organs? Furthermore, justice and law can be two different concepts. The last mentioned must contain the basic support of the previous. When this does not happen, many people feel the need to go against the legal structure, resulting in a lack of faithfulness in all laws. One of the examples could be the era when people rebel against legal rights, which have moved against a greater sense of justice, for instance, the social institution against discriminatory laws in America (Garry, 2000). Some laws are unjust to extent that is justifiable to disobey them and even to go against the government, which established them. This shows how the America came in being. There are many examples of unjust laws seen in the text. Many Americans took the assumption of imperfect laws as they were established in the constitution. This implied that the wrong had trumped what was right. Indeed, many argue that with no fancy of good law used to fight evil laws, as many people know that it would never evolve. It is the duty of the free men and women to rise and fight the unjust laws since the imperfect laws attack the peoples liberty. First, the declaration and the United States constitution protect life, property and liberty. Yet many people believe that this is the wicked threat to all these. This decision is lawless. Extremely lawless This is because many lawyers who were in black robes of which one was purported to be conservative. These men used to issue improper decisions. This made the people to be stunned. Currently, the Supreme Court, the ruling institution made to protect the people from the tyranny decided to follow the constitution made. The court claimed to protect the peoples rights, tho it was unjust to the people. This made the pe ople work hard so as to elect a unused president. Many famous legal expositors stated clearly and explicitly that imperfect law is not natural covering to consider. Many laws are contrary to human good and they are not to all. This implies that if a law is not applied to all, then this is unjust. All people should be equal before the law and, therefore, not discriminated. The unjust laws force many judges to choose between

Rawls's Theory of Distributive Justice Essay Example | Topics and Well Written Essays - 1250 words

Rawlss Theory of Distributive Justice - Essay ExampleRawlss possibility has an historical root from complaisant narrow tradition that is associated with Thomas John Locke and Jean-Jacques Rousseau. Traditional social contract supposition addresses a state of nature that describes the content of a social contract which is an agreement to destroy civil society. Distributive justice deals with the questions of distribution of liberties, wealth, and income (Rawls, 2003) fit in to Rawls there argon two principles that be conjectural to govern the basic makeup of a just society are the parties to the original position an complex number circumstance which specially constructed by a rational individual. The principles are (a) the principle of suitable liberty and social justice where each individual has equal claim to adequate basic rights and liberties. In this system there are equal political liberties with guaranteed fair share. (b) The difference principle there are social and scotch inequalities that are attached to positions which are open to all under conditions of equal opportunity, and they are to benefit correct the least advantaged member in the society (Rawls, 2003). According to this principle, an inequality can benefit the person who gets the smaller share. Inequalities can form incentives which increase the size to shared, so that the smaller piece may be larger in absolute terms. The difference principle deals with strict equality under circumstances where differences in income and some other rewards do non affect the incentives of an individual. On the other hand, in the real world currently, greater rewards submit forth greater productive effort, thus increasing the total wealth of the economy and therefore the wealth of the least advantaged (Rawls, 2003). Rawls argues that if the skilled and motivated increase their rewards then the poor will benefit than they would have been by equal allocation of income. He also realizes that redi stribution cannot go as far as his moral gustation for equality without making everyone worse off. He argues for inheritance taxes because unregulated transfer of wealth through extension would end up in the accumulation of wealth in given section of society. According to Rawls, individuals who are not lucky enough to have wealthy parents do not have worse scratch line points than those who were so fortunate. He contends that society should tax the wealthy with the undeserved inherited gain of children of rich persons (Gerald, 1999). According to Rawls such a system of justice will limit the unfair resources and encourage the redistribution which will choose the disadvantaged. For Rawls it is unfair to leave the disadvantaged in no better position than before, even if the inequality does not harm them. In this way he emphasized the distribution type of justice which favored equal distribution of basic commodities like income and wealth. Practically, it implies that in difference principle, the society must distribute wealth up to the extent that the wealth of the most disadvantaged is improved. In essence the society must tax and allocate wealth of wealthy individual to the point where their incentive to generate more just fade away. Rawls describes his theory as political because it does not depend on assumptions that are usually unclear to rational citizens in a pluralistic society. He argues that justice require equality as it complies where everyone has fair equal rights and liberties. To Rawls disagreements are resolved on the basis of prior agreement

What finding meaning in life is for you Essay Example | Topics and Well Written Essays - 500 words

What conclusion meaning in life is for you - Essay ExampleAs we transition from childhood to adulthood, our experiences and mental capacities target us in different directions. For example, in a school with 200 students who go through the aforementioned(prenominal) syllabus and share the same experiences, not all of them end up in similar careers. several(prenominal) will find fulfillment in music, others will be inclined to pursue art, while or so will end up settling in politics. In all the students, however, the common denominator is the fact that each of them sees their futures in different areas (Zimmerman 34). Individuals gravitate towards different things when seeking meaning in life, and this is what lead to fulfillment in different aspects.Meaning in life changes over time, but it can also be rigid. Again, this comes dorsum to individual preferences and character. For example, at some point (e.g., in college) some people seek professional prosperity over other issues. However, once they attained this they start leaning towards other interests that they think are skilful as important in life. For example, a senior student in college may think, for a unyielding time that getting a good job is the essence of life (Zimmerman 49). However, after building a successful career, the student may discover that having a family is the most important thing in life. As such, the career becomes secondary to family life. Other individuals may discover a newfound passion for business and connection service, and then consider this to be the basis for their lives, relegating previous meanings to minor roles.The essence of a forgiving being is to understand oneself and becoming self-actualized. This is part of finding meaning in life and that is what separates humans from animals. human race beings need to become aware of their surroundings, their priorities, and their trajectories (Zimmerman 83). In general, people who can be classified as having no meaning in life are often less

Biomedical Informatics Essay Example | Topics and Well Written Essays - 1500 words

Biomedical Informatics - Essay display caseHistorians have found evidence of the disease as far back as 5000 B.C. It was first describe as the shaking palsy in 1817 by British doctor James Parkinson. Because of paralysis agitans ahead of time work in identifying symptoms, the disease came to bear his name.In the normal wizard, some nerve cells produce the chemical substance dopamine, which transmits signals within the caput to produce smooth movement of muscles. In Parkinsons patients, 80 percent or more of these dopamine-producing cells atomic number 18 damaged, dead, or otherwise degenerated. This causes the nerve cells to fire wildly, leaving patients unable to control their movements. Symptoms normally show up in one or more of four waysThis diagram of the brain shows several structures related to Parkinsons disease. Basal ganglia affect normal movement and walking substantia nigra ar types of basal ganglia that produce the neurotransmitter dopamine, which sends messages th at control muscles. The globus pallidus is part of a larger structure connected to the substantia nigra affecting movement, balance and walking. The thalamus serves as a relay station for brain impulses, and the cerebellum affects muscle coordination.Though full-blown Parkinsons can be crippling or disabling, experts say early symptoms of the disease may be so subtle and gradual that patients sometimes ignore them or attribute them to the effects of aging. At first, patients may line up overly tired, down in the dumps, or a little shaky. Their speech may become salving and they may become irritable for no reason. Movements may be stiff, unsteady, or unusually slow.Ref www.fda.gov/fdac/features/1998/498_pd.html - basic PD research over the last several decades, including contractables, molecular and cellular biology, characterization of neural circuitry, brain anatomy, and neurochemistry, has formed the basis of therapeutic research being currently pursued for PD. While the cause s of PD are still not fully understood, the most prevalent theories suggest that toxic accumulation of protein in cells, dysfunctional protein clearance, and oxidative stress that leads to cell death are primary causal pathways. There is now genetic evidence for each of these pathways, and a prevailing research strategy is to identify points in these pathways that could be victimised for therapeutic benefit. Todays basic science research continues to span a diverse array of fields, from genes and molecules, through cells and physiologic systems, to the role of the environment and its interaction with genetic susceptibility. It is expected that these studies will continue to inform preventive strategies and let on treatments for PD in the future. The Genetics and Cell Biology of Parkinsons disease One of the most rummy transformations in PD research over the last decade was the identification of the first gene to be associated with PD, -synuclein. The discovery that genetic mutat ions could cause PD brought a sea change to a field that had antecedently focused only on environmental causes of the disease. Since the discovery of alpha synuclein in

Compare and contrast the marketing strategies used by Waitrose and Essay

Compare and contrast the food marketing strategies used by Waitrose and ASDA in UK . How do they determine the needs of their customer - Essay ExampleThe product should as well better the lives on the customers, who should forever and a day desire to come back for much this keeps a phone line at a competitive return since it is cap satisfactory of sustaining its customers. A marketing dodge should also be consistent such that, the marketing core remains the same. In this case, consumers will be certain of the product being sold. Hence, one should choose a certain appropriate market for his business and the marketing channels. In addition, a market for a business should be targeted such that, it is directed to the right customers. Normally, proper communication using right words attracts customers more hence, an effective marketing strategy must be communicative (Hoos, 2010). Marketing strategies are inclusive of three forces, namely, competitor, customer, and corporation. Ac cording to Jain, a good marketing strategy should include a clear market definition, a good match between corporate strengths and the needs of the market and a superior performance, relative to the arguing in the key success factors of the business (Jain n.d, pp 23). A good matching of the customer and corporations needs and objectives is important since it leads to a long relationship however, tilt must have an objective, for instance, the level of competition, which entails whether competition involves an entire market or a in a certain segment. Secondly, how to compete entails the means by which competition will take place, for instance, a product may be introduced to serve a particular proposition customers need. Thirdly, when to compete involves a waiting for a certain time to penetrate into the market (Jain, n.d, pp 24). Therefore, according to Analoui (2003, pp 241), an effective marketing strategy should prioritize demands and wants of customers, identify a market for the business, select a marketing mix and drive the firm in to a competitive advantage. Marketing strategies used by Waitrose and ASDA in United Kingdom and how they identify their customers Waitrose was founded by Wallace Waite, Arthur Rose, and David Taylor, when the self-service for product was introduced in 1951. However, it operates as a grocery retailer in the United Kingdom, and it is aimed at providing the convenience as supermarkets do, in terms of run and products that are of prize, value, and fresh and in variety. Waitrose mainly deals with food and drinks and targets the upper market, providing variety of their fresh and quality products. However, Waitrose faces competition from related firms like the Tesco this is due to Waitroses high prices, while consumer are capable of buying groceries in any place as long as the prices are friendly and the groceries are fresh. However, one of the strategy Waitrose has adapted in order to attract and sustain customers is product differ entiation and delivering product of high quality (Addidas 2003, pp 5). According to Chadwick et al, (2007 pp 14), Waitrose acquired 40% in LMS e-commerce grocery business to expand its online service. Due to technology, the online service was effective and able to serve customers anywhere in terms of home delivery of groceries

The Elimination of Poverty Research Paper Example | Topics and Well Written Essays - 1500 words

The Elimination of Poverty - Research Paper ExampleCounterfactuals allow us to take down a universe of possibility one where we can non be in the normal state of affairs exactly only in a kind of imaginary state of examination. Having said this, it should be clear that contrasted to fact analysis has little to do with reality or practical application. The conclusions reached here about what if can verify nothing to inform public policy that deals with the here and now. In fact, precisely beca intake the antecedent in this miscue cannot be true (as was said previously), it faculty be the case that these considerations cannot have any practical use beyond the useful practice of logical conjecture.What if exiguity were eliminated? Such a question presupposes that we know what poverty is, beyond the concepts that we use in day-to-day life. However, what we find with these common concepts is that they are often faulty and not representative of the actual state of affairs. For insta nce, while we might think of justice as fairness, this might ungenerous that justice is the property of abiding by rules. The rules themselves could in fact be unjust themselves. The concept of poverty, alike(p) justice, bears hidden connotations that must be sheared off before continuing. There are actually cardinal components of the concept of poverty, one of which has to do with economics and the other which has to do with personal properties. These two facets of poverty promptly interact with one another and often reinforce one another. The elimination of one kind of poverty, contrary to popular belief, will not lead automatically or ensure the elimination of the other, which perpetuates the problem and has the dominance to move us into committing evil acts.The first facet of poverty is that of virtue. While the word virtue might sound overly philosophical, it is merely a matter of personal excellence. A virtue is a reputation trait that serves as a means to a greater end. For instance, the virtue of a